He worked on the mechanism of recovery from pneumonia and was noted for early work on surface phagocytosis, research into the pathogenesis of fever, and endogenous pyrogen ( now known as interleukin-1 ).
2.
However, in contrast to these two endogenous pyrogens, the fever induced by MIP-1 is not inhibited by the cyclooxygenase inhibitor ibuprofen and CCL3 may participate in the febrile response that is not mediated through prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase.
3.
Bartfai s group showed IL-1, then called the endogenous pyrogen, occurs and can be released from the adrenal medulla and brain and demonstrated that the endogenous pyrogen can control body temperature by acting at IL-1 receptors and hyperpolarizing hypothalamic gabaergic interneurons that control thermogenesis in brown adipose tissue ( BAT ), and thus core body temperature and the fever response .,
4.
Bartfai s group showed IL-1, then called the endogenous pyrogen, occurs and can be released from the adrenal medulla and brain and demonstrated that the endogenous pyrogen can control body temperature by acting at IL-1 receptors and hyperpolarizing hypothalamic gabaergic interneurons that control thermogenesis in brown adipose tissue ( BAT ), and thus core body temperature and the fever response .,
5.
IL-1? is also known as fibroblast-activating factor ( FAF ), lymphocyte-activating factor ( LAF ), B-cell-activating factor ( BAF ), leukocyte endogenous mediator ( LEM ), epidermal cell-derived thymocyte-activating factor ( ETAF ), serum amyloid A inducer or hepatocyte-stimulating factor ( HSP ), catabolin, hemopoetin-1 ( H-1 ), endogenous pyrogen ( EP ), and proteolysis-inducing factor ( PIF ).
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