In affected cells, this protein builds up and assembles intranuclear inclusion bodies.
2.
Inflammation and intranuclear inclusions also have been described.
3.
The protein fragments form abnormal clumps, known as neuronal intranuclear inclusions ( NIIs ), inside nerve cells, and may attract other, normal proteins into the clumps.
4.
Ataxin-3 is the protein that, in the deubiquitinating enzyme function, forms SCA type-1 and 2 DRPLA intranuclear inclusions ( the regular wild-type protein localized to inclusion bodies ).
5.
The SN test is occasionally used for detection and quantitation of humoral antibody for PPV . Neutralization of infectivity is usually confirmed by the absence or reduction either of intranuclear inclusions or fluorescent cells in cultures or of viral hemagglutinin in the culture medium.
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