| 1. | The priming event on the lagging strand establishes a replication fork.
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| 2. | The lagging strand is synthesized in short, separated segments.
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| 3. | In contrast, lagging strand synthesis is accomplished in short Okazaki fragments.
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| 4. | The leading strand receives one RNA primer while the lagging strand receives several.
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| 5. | A DNA polymerase I molecule ( green ) binds to the lagging strand.
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| 6. | DNA ligase then joins the deoxyribonucleotides together, completing the synthesis of the lagging strand.
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| 7. | However, there is a problem going in the other direction on the lagging strand.
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| 8. | However, significant challenges remain : the leading and lagging strands are anti-parallel.
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| 9. | On the leading strand this route is continuous, but on the lagging strand it is discontinuous.
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| 10. | During lagging strand synthesis, the replicative polymerase sends the lagging strand back toward the replication fork.
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