| 1. | Recent studies have contended that Pol? may synthesize the leading strand.
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| 2. | The leading strand receives one RNA primer while the lagging strand receives several.
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| 3. | In most bacteria majority of the genes are encoded in the leading strand.
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| 4. | Yeast studies have shown that Pol? can proofread Pol? errors on the leading strand.
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| 5. | Next, DNA polymerase III ( green ) produces the leading strand copy ( red ).
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| 6. | On the leading strand this route is continuous, but on the lagging strand it is discontinuous.
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| 7. | Leading strand synthesis then proceeds continuously, while the DNA is concurrently unwound at the replication fork.
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| 8. | This means that nucleotide synthesis on the leading strand naturally occurs in the 5'to 3'direction.
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| 9. | The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication.
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| 10. | This polymerase synthesizes leading strand DNA in eukaryotes . ( Thought to form an asymmetric dimer with DNA polymerase delta .)
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