HDACs appear to be important for the continued maintenance of latency as HDAC inhibitors induce a lytic infection.
2.
This contrasts other genes normally found in lytic infection that are not associated with acetylated H3K9 histones during latency.
3.
Once EBV's initial lytic infection is brought under control, EBV latency persists in the individual's B cells for the rest of the individual's life.
4.
EGCG, a polyphenol in green tea, has shown in a study to inhibit EBV spontaneous lytic infection at the DNA, gene transcription and protein levels in a time and dose-dependent manner; the expression of EBV lytic genes Zta, Rta, and early antigen complex EA-D ( induced by Rta ), however, the highly stable EBNA-1 gene found across all stages of EBV infection is unaffected.
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