mossy fibre वाक्य
उदाहरण वाक्य
मोबाइल
- CA3 via mossy fibres ( synapse 2 ), CA3 ?
- Mossy fibre sprouting continues from one week to two months after injury.
- Stimulation of aberrant mossy fibre areas increases the excitatory postsynaptic potential response.
- Each granule cell is receiving an input from two different mossy fibre inputs.
- Aberrant mossy fibre sprouting may create excitatory feedback circuits that lead to temporal lobe seizures.
- Additionally the GABA acts on GABA-B receptors which are located presynaptically on the mossy fibre terminal.
- These inhibit the mossy fibre evoked EPSCs of the granule cell in a temperature and frequency dependent manner.
- In TLE, the sprouting mossy fibres are larger than in the normal brain and their connections may be aberrant.
- Also, in animal models, granule cell hyper-excitability is recorded before aberrant mossy fibre sprouting has occurred.
- Marr proposed that the granule cells encode combinations of mossy fibre inputs, and that the climbing fibres carry a " teaching " signal that instructs their Purkinje cell targets to modify the strength of synaptic connections from parallel fibres.
- This pause response, called a Purkinje cell CR, was also obtained when direct mossy fibre stimulation was used as the CS and direct climbing fibre stimulation as the US . Unpaired presentations of the CS and US caused extinction of the Purkinje cell CR . When paired presentations were reintroduced after extinction, Purkinje cell CRs reappeared rapidly, mirroring the " savings " phenomenon demonstrated at the behavioral level.
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