| 1. | HMG-CoA reductase null alleles or mutations, simvastatin therapy may actually be toxic.
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| 2. | These 4 microsatellite loci were all prone to null alleles.
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| 3. | However, with the presence of these null alleles, the results may have been slightly biased.
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| 4. | Thus we may consider the allele for the O blood type as a null allele.
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| 5. | DRB1 * 0710N is a null allele.
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| 6. | Alternatively, the technique can be used to create null alleles so that the gene is not functional.
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| 7. | However, the frequency of heterozygous null alleles is much higher than expected, indicating a heterozygous advantage for TPI null alleles.
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| 8. | However, the frequency of heterozygous null alleles is much higher than expected, indicating a heterozygous advantage for TPI null alleles.
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| 9. | In fact, the mutants for these genes do not show the usual phenotype, that of the null alleles of A genes.
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| 10. | Other mutations, which inactivate the enzyme ( = null alleles ) are lethal when inherited heterozygotes ( one defective and one normal copy ).
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