CD48 is expressed on all peripheral blood lymphocytes ( PBL ) including T cells, B cells, Null cell and thymocytes.
2.
Studies show that c-jun is required for progression through the G1 phase of the cell cycle, and c-jun null cells show increased G1 arrest.
3.
Actually, they report that the ribonucleotides are being incorporated 1 every ~ 7.600 nt in null cells = 1.300.000 lesions per cell.
4.
The majority of the underlying tumors are " null cell " or nonsecretory tumors, which do not produce excessive amounts of hormones; this might explain why the tumor has often gone undetected prior to an episode of apoplexy.
5.
Ribonucleotide accumulate in RNaseH2 null cells as a consequence of incorporation by DNA polymerases : The authors show that the ribonucleotide incorporation also occurs in metazoans, these lesions are harmful to mammalian cells, and their removal is required for mouse embryonic development.
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