Ehrlich rejected inheritance in the genetic sense because the offspring of a male mouse immunized against abrin and an untreated female mouse were not immune to abrin.
12.
The plant is best known for its seeds, which are used as beads and in percussion instruments, and which are toxic because of the presence of abrin.
13.
The later signs and symptoms of exposure are caused by abrin's cytotoxic effects, killing cells in the kidney, liver, adrenal glands, and central nervous system.
14.
Initial symptoms of abrin poisoning by inhalation may occur within 8 hours of exposure but a more typical time course is 18 24 hours; they can prove fatal within 36 72 hours.
15.
The toxin abrin is a subunits, termed A and B . The B chain facilitates abrin's entry into a cell by bonding to certain transport proteins on cell membranes, which then transport the toxin into the cell.
16.
The toxin abrin is a subunits, termed A and B . The B chain facilitates abrin's entry into a cell by bonding to certain transport proteins on cell membranes, which then transport the toxin into the cell.
17.
By attaching to a carbohydrate chain on the cell surface, the abrin molecule anchors itself to the cell, is subsequently engulfed and enters the inner parts of the cell where it reacts with a ribosomal subunit and interferes with the normal protein synthesis process of the cell.
18.
Among the RIPs are some of the most toxic molecules known, including ricin and abrin ( the latter is the poison preferred by the characters in " enzymatically inactivate the ribosomes, shutting down protein synthesis and resulting in cell death, and eventually causing death of the victim.
19.
But the depth of Hutchkinson's antagonism is unmistakable : he suggests that readers kill Catholics by soaking their rosary beads in Phytotoxin abrin, a toxin derived from a rare bean; he writes that botulinum is " fun and easy to make "; and he urges survivalists around the world to hone their skills, readying themselves for biological warfare in the coming Armageddon.
20.
Symptoms are identical to those of ricin, except abrin is more toxic by almost two orders of magnitude; the fatal dose of abrin is approximately 1 / 75th that of the fatal dose of ricin ( though the abrin in ingested seeds may be absorbed much more slowly than the ricin in " Ricinus communis " even if the seeds are chewed and the coat penetrated, allowing time for successful rescue efforts in at least some cases . ) Abrin has an of only 0.56 ?g / kg in mice, and Kingsbury lists a toxic dose in humans at 0.00015 % body weight, or approximately 0.1 mg for a 150 lb human.
