Chlorination at with aluminium chloride and acetyl chloride yields equal amounts of 1-and 4-chlorodiamantane, whereas use of chlorosulfonic acid yields mainly the 1-chloro isomer.
12.
In 1853, chemist Charles Fr�d�ric Gerhardt treated acetyl chloride with sodium salicylate to produce acetylsalicylic acid for the first time; in the second half of the nineteenth century, other academic chemists established the compound's chemical structure and devised more efficient methods of synthesis.
13.
It is produced in the same fashion as other esters of morphine-- treating morphine with an acid anhydride ( or some acids or other relatives of acids like acetyl chloride ) to get a mono-, di-, tri-, or tetra-ester.
14.
In 1853, chemist Charles Fr�d�ric Gerhardt treated acetyl chloride with sodium salicylate to produce acetylsalicylic acid for the first time; The word " Aspirin " was Bayer's brand name, rather than the generic name of the drug; however, Bayer's rights to the trademark were lost or sold in many countries.
15.
It undergoes Friedel-Crafts acylation with acetyl chloride and aluminium chloride to give the acyl derivative "'2 "', with formaldehyde and hydrochloric acid to the chloromethyl derivative "'3 "', in a Vilsmeier-Haack reaction with N-methylformanilide and phosphorus oxychloride to the formyl "'4 "', and in a Mannich reaction to amine derivative "'5 " '.
16.
Both were developed in Austria in the 1920s along with other derivatives of the strong dihydromorphinones and these drugs are generated by reacting oxymorphone with either acetic anhydride or acetyl chloride at various temperatures in the 80-160 �C for several hours; 3, 6, 14-triacetyloxymorphone may be more easily made when a catalylst is used but elevated pressure or reaction " in vacuo " or under a nitrogen or noble gas atmosphere is not required.
