When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase.
12.
Aconitase is one of several iron-sulfur-containing ( de ) hydratases in metabolic pathways shown to be inactivated by superoxide.
13.
An example of feedback inhibition in human cells is the protein aconitase ( an enzyme that catalyses the isomeration of citrate to isocitrate ).
14.
Aconitase catalyzes " trans " elimination / addition of water, and the flip guarantees that the correct stereochemistry is formed in the product.
15.
The glyoxylate cycle utilizes five of the eight enzymes associated with the tricarboxylic acid cycle : citrate synthase, aconitase, succinate dehydrogenase, fumarase, and malate dehydrogenase.
16.
Another disease associated with aconitase is Friedreich's ataxia ( FRDA ), which is caused when the Fe-S proteins in aconitase and succinate dehydrogenase have decreased activity.
17.
Another disease associated with aconitase is Friedreich's ataxia ( FRDA ), which is caused when the Fe-S proteins in aconitase and succinate dehydrogenase have decreased activity.
18.
The mitochondrial form of aconitase, ACO2, is correlated with many diseases, as it is directly involved in the conversion of glucose into ATP, or the central metabolic pathway.
19.
Isotope scrambling experiments using tritium, deuterium, and 18 O were carried out on the aconitase hydratase reaction by I . A . Rose and E . L . O'Connell.
20.
Finally, aconitase is thought to be associated with diabetes . ) and genetic diabetes, lower aconitase activity was found to decrease the rates of metabolic reactions involving citrate, pyruvate, and malate.
