| 11. | Ketamine appears to inhibit the NMDAR by binding both in the open channel and at an allosteric site.
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| 12. | Allosteric sites allow effectors to bind to the protein, often resulting in a conformational change involving protein dynamics.
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| 13. | It also binds to the allosteric site of the serotonin transporter, similarly, but less potently than escitalopram.
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| 14. | Ganaxolone binds to allosteric sites of the GABA A receptor to modulate and open the hyperpolarization of the neuron.
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| 15. | In addition to their high substrates such as cocaine and indatraline have lower affinity for these allosteric sites as well.
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| 16. | The allosteric site of AMP binding on muscle isoforms of glycogen phosphorylase are close to the subunit interface just like Ser14.
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| 17. | They appear to exert their reuptake inhibition by binding to vaguely characterized allosteric sites on each of the respective monoamine transporters.
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| 18. | Allosteric sites are pockets on the enzyme, distinct from the active site, that bind to molecules in the cellular environment.
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| 19. | Allosteric activators such as PEP bind to the same allosteric site and facilitate the formation of the T state, thereby inhibiting enzyme activity.
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| 20. | For example, when 2, 3-BPG binds to an allosteric site on hemoglobin, the affinity for oxygen of all subunits decreases.
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