There is an inability to excrete H + while cannot be reclaimed by the cell, leading to acidemia ( as builds up in the body ) and hypokalemia ( as cannot be reabsorbed by the alpha cell ).
12.
The hormone glucagon was discovered by C . P . Kimball and John R . Murlin in 1923 as a cobalt-damage alpha cells stopped producing glucagon in guinea pigs, and finally isolated the purified hormone in 1953, including those from birds.
13.
If the blood glucose level drops lower than this, especially to dangerously low levels, release of hyperglycemic hormones ( most prominently glucagon from islet of Langerhans alpha cells ) forces release of glucose into the blood from the liver glycogen stores, supplemented by gluconeogenesis if the glycogen stores become depleted.
