The unique mode of action or MOA of ?-amanitin seems to make the amanitin-based antibody-drug conjugates a suitable toxic payload.
12.
The unique mode of action or MOA of ?-amanitin seems to make the amanitin-based antibody-drug conjugates a suitable toxic payload.
13.
Many other sporocarps are grazed upon by invertebrates such as mollusks and fly larvae, some of which are even tolerant to the toxic ?-amanitin.
14.
Furthermore, amanitin has a water-soluble structure, resulting in antibody-drug conjugates with low tendency for aggregation, even using higher drug to antibody ratios or DAR.
15.
Because it inactivates the RNA polymerases, the liver is unable to repair the damage that beta-amanitin causes and the cells of the liver disintegrate and the liver dissolves.
16.
Like other amatoxins, ?-amanitin is an inhibitor of RNA polymerase II . Upon ingestion, it binds to the RNA polymerase II enzyme which completely prevents kidney cells.
17.
Structure of eukaryotic RNA polymerase II ( light blue ) in complex with ?-amanitin ( red ), a strong poison found in death cap mushrooms that targets this vital enzyme
18.
Due to its lethality and its widespread presence in the Amanita family, which is found across the globe, ?-amanitin has been extensively studied in the field of Protein Biochemistry.
19.
In this study, the amanitin amounts from certain " Galerina " specimens were higher than those from some " Amanita phalloides ", a European fungus generally considered as the richest in amanitins.
20.
Patients hospitalized and given aggressive support therapy almost immediately after ingestion of amanitin-containing mushrooms have a mortality rate of only 10 %, whereas those admitted 60 or more hours after ingestion have a 50 90 % mortality rate.
