| 11. | The pharmacophore can be characterized as amphipathic, that means that the structure has both hydrophobic and hydrophilic groups.
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| 12. | A biological membrane is a kind of amphipathic layer that acts as a barrier within or around a cell.
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| 13. | The C-terminal amphipathic alpha helix is also the site of lacritin's only N-glycosylation site.
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| 14. | Epsin has an ENTH ( epsin N-terminal homology ) domain which inserts its amphipathic alpha helix into the membrane.
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| 15. | In one study, a short amphipathic peptide carrier, Pep-1, and protein complexes have proven effective for delivery.
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| 16. | Membrane association depends on a pleckstrin homology domain, as well as an amphipathic alpha-helical domain in the amino terminus.
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| 17. | Similar effects to melittin on H +-K +-ATPase have been found with the synthetic amphipathic polypeptide Trp-3.
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| 18. | The MBD amphipathic, with the alpha1 helix and the beta sheet lying parallel and the hydrophobic faces tightly packed against each other.
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| 19. | A helical wheel analysis shows that the membrane spanning alpha helices are amphipathic, with one side being polar and the other side hydrophobic.
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| 20. | Glutamine 106 resides within the amphipathic alpha helix near the C-terminus responsible for binding the N-terminus of syndecan-1.
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