Such an export of the fusion protein into the periplasmic space enables the formation of disulfide bonds in the passenger protein, e . g . antibody fragments.
12.
Afterwards, he conducted postdoctoral research with Professor Fred Blattner on phage display of random peptide libraries and antibody fragment expression in " E . coli " bacteria.
13.
Technically, CAT-3888 is an anti-CD22 immunotoxin fusion protein between a murine anti-CD22 disulfide-linked Fv ( dsFv ) antibody fragment and an edited copy of bacterial Pseudomonas exotoxin PE38.
14.
PEGylation is the process of attaching the strands of the polymer PEG to molecules, most typically peptides, proteins, and antibody fragments, that can improve the safety and efficiency of many therapeutics.
15.
To provide methods for manufacture of antibody fragments on a scale, and at a cost acceptable for application in environmental management and as components of topical pharmaceuticals, cosmeceuticals or consumer goods ."
16.
Initially the insolubility of anti-herbicide antibody fragments when expressed in E . coli had restricted this work, however work later carried out showed that disulfide linked scFvs, termed SCABS, had improved stability in a range of environments.
17.
"' pComb3H "', a derivative of pComb3 optimized for expression of human fragments, is a phagemid used to express proteins such as zinc finger proteins and antibody fragments on phage pili for the purpose of phage display selection.
18.
The group is working toward the development of genetically engineered immunotoxins made from monoclonal antibody fragments genetically fused to either saporin or Pseudomonas exotoxin ( PE ) for the treatment of human hematological malignancies such as leukaemia, lymphoma and multiple myeloma.
19.
If arrhythmias prove troublesome, or malignant hyperkalaemia occurs ( inexorably rising potassium level due to paralysis of the cell membrane-bound, ATPase-dependent Na / K pumps ), the specific antidote is antidigoxin ( antibody fragments against digoxin, trade names Digibind and Digifab ).
20.
"' Ranibizumab "'( trade name "'Lucentis "'among others ) is a monoclonal antibody fragment ( anti-angiogenic that has been approved to treat the " wet " type of age-related macular degeneration ( AMD, also ARMD ), a common form of age-related vision loss.
