Because of their primary effect on DNA synthesis, the antimetabolites are most effective against actively dividing cells and are largely cell-cycle phase specific.
12.
Antifolates, such as pralatrexate, are part of a group of compounds known as antimetabolites with structural similarity to naturally occurring molecules involved in DNA synthesis.
13.
The most widely used inhibitor is 5-Fluorouracil ( 5-FU ), which acts as an antimetabolite that irreversibly inhibits TS by competitive binding.
14.
His subsequent investigations showed that the early biochemical effect of the two epipodophyllotoxins on proliferating cells in-vitro differed from the alkylating agents, antimetabolites and vinca alkaloids.
15.
Megaloblastic anemia not due to hypovitaminosis may be caused by antimetabolites that poison DNA production directly, such as some chemotherapeutic or antimicrobial agents ( for example azathioprine or trimethoprim ).
16.
"' Antifolates "'are a class of antimetabolite medications that antagonise ( that is, block ) the actions of folic acid ( vitamin B 9 ).
17.
Major categories of drug interventions include glucocorticoids, antimetabolites, biologic agents especially monoclonal anti-tumor necrosis factor antibodies, and more recently, specific antibiotic combinations and mesenchymal stem cells.
18.
When elemental fluorine is reacted with uracil, 5-fluorouracil is produced . 5-Fluorouracil is an anticancer drug ( antimetabolite ) used to masquerade as uracil during the nucleic acid replication process.
19.
To do this other anticancer drugs can be utilized such as alkylating drugs ( cyclophosphamide ), antimetabolites ( 5-fluorouracil ), and the anthracycline modified drugs ( annamycin and doxorubicin-peptide ).
20.
On the other hand, therapies with low risk of gonadotoxicity include plant derivatives such as vincristine and vinblastine, antibiotics such as bleomycinand dactinomycin and antimetabolites such as methotrexate, mercaptopurine and 5-fluoruracil.
