Those with asplenia are also cautioned to start a full-dose course of antibiotics at the first onset of an upper or lower respiratory tract infection ( for example, sore throat or cough ), or at the onset of any fever.
12.
In particular, the absence of a functional spleen, through congenital asplenia, splenectomy, or sickle-cell disease predisposes one to a more severe course of infection ( Overwhelming post-splenectomy infection ) and prevention measures are indicated ( see asplenia ).
13.
In particular, the absence of a functional spleen, through congenital asplenia, splenectomy, or sickle-cell disease predisposes one to a more severe course of infection ( Overwhelming post-splenectomy infection ) and prevention measures are indicated ( see asplenia ).
14.
Children at special risk ( e . g ., sickle cell disease and asplenia ) require as full protection as can be achieved using the 7-valent conjugated vaccine, with the more extensive 23-valent vaccine given after the second year of life:
