In collaboration with colleagues at Columbia University Licinio and his team showed that inflammation-mediated up-regulation of secretory sphingomyelin phosphodiesterase in vivo represents a possible link between inflammatory cytokines and atherogenesis.
12.
Chaldakov developed a complex tripartite model of atherogenesis which involve smooth muscle cells, immune cells, and perivascular adipose tissue communicating through secreted factors ( e . g . neurotrophins, adipokines, cytokines ).
13.
His work on LOX-1 receptors, its polymorphic variants and its role in atherogenesis and myocardial ischemia has led to new therapeutic targets now being pursued by several biotech companies, such as MedImmune.
14.
In other investigations, the team has identified novel lymphocyte, dendritic cell and macrophage chemoattractants and receptors, as well as monocyte and arterial wall endothelial molecules that regulate monocyte-endothelial interactions in models of atherogenesis.
