I'm trying to figure out why dimedone is almost as acidic as barbituric acid, compared to other diketones ( 3 pKa drop ).
12.
Another proposed use of physostigmine is to reverse the effects of barbiturates ( any of a group of barbituric acids derived for use as sedatives or hypnotics ).
13.
Regarding barbituric acid, was it ever proven whether the reported thermodynamic pKa is actually for the doubly-? position rather than an amide N-H?
14.
A mixture containing citric acid, monopotassium phosphate, boric acid, and diethyl barbituric acid can be made to cover the pH range 2.6 to 12.
15.
Barbituric acid itself does not have any direct effect on the central nervous system and chemists have derived over 2, 500 compounds from it that possess pharmacologically active qualities.
16.
This yellow green compound is prepared by addition of ammonia to o-phthalonitrile to give the diiminoisoindoline, which in turn condenses first with N-methylcyanoacetamide and then with barbituric acid.
17.
Barbiturates can in most cases be used either as the free acid or as salts of sodium, calcium, potassium, magnesium, lithium, etc . Codeine-and Dionine-based salts of barbituric acid have been developed.
18.
One thing I've been thinking about is homoaromaticity ( and the aromaticity-stabilisation for barbituric acid probably is significantly reduced because of the number of heteroatoms and EWGs involved ) . talk ) 17 : 23, 25 April 2010 ( UTC)
