| 11. | Upon heating a solution of this complex, methane was lost, leaving the benzyne complex:
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| 12. | It is a member of the unsaturated polycyclic hydrocarbons class of compounds and a tetramer of benzyne.
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| 13. | The o-benzyne intermediate can be visualized in the two resonance ( chemistry ) forms illustrated above.
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| 14. | Fluoride displacement of the trimethylsilyl group, as shown below, allows for generation of benzyne under mild conditions.
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| 15. | Many radiomimetic compounds are enediynes, which undergo the Bergman cyclization reaction to produce the para-benzyne diradical.
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| 16. | The p-benzyne diradical is highly reactive, and will abstract hydrogens from any possible hydrogen-donor.
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| 17. | In 1953 John D . Roberts performed the classic 14 C labeling experiment, which provided strong support for benzyne.
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| 18. | The discovery of benzyne led to rapid developments in synthetic methodologies to make this highly reactive intermediate useful for organic synthesis.
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| 19. | Soon after Roberts discovery, Wittig and Pohmer found that benzyne can participate in [ 4 + 2 ] cycloaddition reactions.
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| 20. | The free radical then continues on to cleave DNA in a similar manner to p-benzyne in order to treat cancerous cells.
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