The CBR is the whole-body concentration of a chemical that is associated with a given adverse biological response and it is estimated using a partition coefficient and a bioconcentration factor.
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These include : octanol-water partition coefficients ( K OW ), bioconcentration factors ( BCF ), bioaccumulation factors ( BAF ) and biota-sediment accumulation factor ( BSAF ).
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Bioaccumulation and bioconcentration result in buildup in the adipose tissue of successive trophic levels : zooplankton, small nekton, larger fish, etc . Anything which eats these fish also consumes the higher level of mercury the fish have accumulated.
