The Brachyury ( T ) gene, which is expressed in the ascidian notochord, is not expressed in the stomochord, and collagen is absent.
12.
Overexpression of " brachyury " has been linked to Hepatocellular carcinoma ( HCC, also called malignant hepatoma ), a common type of liver cancer.
13.
Expression of the brachyury gene has been identified as a definitive diagnostic marker of chordoma, a malignant tumor that arises from remnant notochordal cells lodged in the vertebrae.
14.
The WNT3 / ?-catenin signalling pathway is essential for the expression of the transcription factor T ( Brachyury ), a transcription factor that is was previously characterized somatic and mesoderm specific genes.
15.
Promoter analysis with the " El Dorado " program from Genomatix predicted that IRX1 expression is regulated by factors that include E2F cell cycle regulators, NRF1, and ZF5, and brachyury.
16.
The chromosomal region on 6q27 containing the brachyury gene was gained in 6 of 21 chordomas ( 29 % ), and none of the 21 chordomas analyzed showed deletions that could have affected this gene.
17.
Also, MACF1 is required for sufficient ?-catenin to travel to the nucleus, where subsequently TCF / ?-catenin-dependent transcriptional activation of a gene T encoding the protein brachyury occurs.
18.
This data indicated the same results as for the " Oct4 " gene, in that heterochromatin is forming as differentiation occurs again coinciding with the silence of " Brachyury " gene expression.
19.
The gene, initially named " TES-56 ", was found to be largely expressed in the Brachyury protein, a T-box transcription factor, which plays a role in establishing symmetry during embryonic development.
20.
Cells that over-express " brachyury " have down-regulated expression of the adhesion molecule E-cadherin, which allows them to undergo EMT . This process is at least partially mediated by the transcription factors AKT and Snail.
