Carbamic acids are intermediates in the decomposition of carbamate protecting groups; the hydrolysis of an ester bond produces carbamic acid the evolution of carbon dioxide drives the deprotection reaction forward, yielding the unprotected amine.
12.
Carbamic acids are intermediates in the decomposition of carbamate protecting groups; the hydrolysis of an ester bond produces carbamic acid the evolution of carbon dioxide drives the deprotection reaction forward, yielding the unprotected amine.
13.
The mechanism involves silylation of the carbonyl oxygen and elimination of " tert "-butyl iodide ( ), methanolysis of the silyl ester to the carbamic acid ( ) and finally decarboxylation to the amine ( ).
14.
"' Carbamic acid "'is the compound with the formula NH 2 COOH . The attachment of the acid group to a nitrogen or amine ( instead of carbon ) distinguishes it from carboxylic acid and an amide.
