The simplest phenotypic screens employ cell lines and monitor a single parameter such as cellular death or the production of a particular protein.
12.
In cases of tissue damage, for example, gatekeeper genes would ensure that balance of cell growth over cellular death remains in check.
13.
Erythema in KWE has been attributed to necrobiosis ( cellular death ) within the malpighian layer ( the innermost layer of the epidermis ).
14.
CL 303268 uncouples oxidative phosphorylation at the mitochondria, resulting in disruption of production of ATP, cellular death, and ultimately organism mortality ."
15.
Other research showed that the products from the first 4, 658 nucleotides of LAT inhibited caspase-8 and caspase-9 cellular death factors.
16.
Cellular death or dysfunction causes a break or faulty signal in the line of communication from the central nervous system to target muscles in the body.
17.
Sustained activation for a longer period of time leads to further mitochondrial swelling, resulting in the release of cytochrome c, which initiates a cascade of cellular death.
18.
Sulston described the visible steps in the cellular death process and demonstrated the first mutations of genes participating in programmed cell death, including a gene known as nuc-1.
19.
Modulations in Bcl-2, Bcl-xL, and endonuclease G from mitochondria are also thought to play a role in safingol-induced cellular death by regulating autophagy.
20.
Apoptotic events such as membrane blebbing, phosphatidylserine flips ( exposure to extracellular space ), mitochondrial swelling, and microvesicle shedding are present, but cellular death does not occur.
