When an allergic reaction leads to anaphylactic shock, it is because cells in the mucosa release chemical mediators which have a systemic effect .-- talk 16 : 18, 20 December 2007 ( UTC)
12.
Once a T cell has recognized its particular antigen on the surface of an aberrant cell, the T cell becomes an activated effector cell, producing chemical mediators known as lymphokines that stimulate macrophages into a more aggressive form.
13.
Activated mast cells and basophils undergo a process called degranulation, during which they release histamine and other inflammatory chemical mediators ( cytokines, interleukins, leukotrienes, and prostaglandins ) from their mucous secretion, nerve stimulation, and smooth muscle contraction.
14.
This feature is critical to its pharmacological effects because a typical anti-IgE antibody can cross-link cell surface Fc?RI-bound IgE, thereby aggregate Fc?RI, and activate mast cells and basophils to discharge the horde of chemical mediators stored in the densely packed sacs inside the cells.
15.
"' Mast cell activation syndrome "'( "'MCAS "'), also commonly referred to as "'mast cell activation disorder "'( "'MCAD "'), is an immunological condition in which mast cells inappropriately and excessively release chemical mediators, resulting in a range of chronic symptoms, sometimes including anaphylaxis or near-anaphylaxis attacks.
