Since it is known to be associated with metastasis and malignant transformation, Bmi-1 makes for a good marker of cancer and may hold prognostic or diagnostic value . and it is known for its association with chemoresistance to common chemotherapeutics.
12.
In colorectal cancer, ABCB5 was shown to act as a mediator of 5-FU patient chemoresistance, and had a further direct role in tumorigenesis shown by shRNA-mediated colorectal cancer cell-line ABCB5 knockdowns that impeded tumorigenesis in human-to-mouse xenografts.
13.
This indicates that MK caused the cells to initiate the survival pathway ( via PKB, mTOR, and Bad activation ) and inhibit the senescent or apoptotic pathway ( via inhibiting caspase-3 ) encouraging the chemoresistance seen in resistant cells and in the co-culture experiments.
14.
Hyperthermia has also been shown to help prevent or reverse " chemo-resistance . " Chemotherapy resistance sometimes develops over time as the tumors adapt and can overcome the toxicity of the chemo medication . " Overcoming chemoresistance has been extensively studied within the past, especially using CDDP-resistant cells.
15.
In regard to the potential benefit that drug-resistant cells can be recruited for effective therapy by combining chemotherapy with hyperthermia, it was important to show that chemoresistance against several anticancer drugs ( e . g . mitomycin C, anthracyclines, BCNU, melphalan ) including CDDP could be reversed at least partially by the addition of heat.
