Timing is crucial, and coxsackieviruses, rotaviruses and lymphocytic choriomeningitis virus that can be protective when given very early and can provoke autoimmunity when given late ( for instance at weaning ).
12.
Unlike most enveloped viruses which use clathrin coated pits for cellular entry and bind to their receptors in a pH dependent fashion, Lassa and lymphocytic choriomeningitis virus instead use an endocytotic pathway independent of clathrin, caveolin, dynamin and actin.
13.
In 1964, Traub published a study for the Army Biological labs in Frederick, Maryland on Eastern Equine Encephalomyeltitis ( EEE ) immunity in white mice and its relationship to Lymphocytic choriomeningitis ( LCM ), which had long been a research interest of his.
