In it Burnet expanded the ideas of Talmage and named it " clonal selection theory . " He further formalised the theory in his 1959 book " The Clonal Selection Theory of Acquired Immunity ".
12.
In it Burnet expanded the ideas of Talmage and named it " clonal selection theory . " He further formalised the theory in his 1959 book " The Clonal Selection Theory of Acquired Immunity ".
13.
The theory is now sometimes known as Burnet's clonal selection theory, which overlooks the contributions of Ehrlich, Jerne, Talmage, and the contributions of Lederberg, who conceptualised the genetics of clonal selection.
14.
Immunology in particular became linked with molecular biology, with innovation flowing both ways : the clonal selection theory developed by Niels Jerne and Frank Macfarlane Burnet in the mid-1950s helped shed light on the general mechanisms of protein synthesis.
15.
Major historical contributions including publication by Donald Metcalf of the strategy for identifying colony-stimulating factors ( CSFs ) and the development of the clonal selection theory by Frank Macfarlane Burnet, in a series of more than 90 publications in the 1970s.
16.
He was the first to establish that influenza is an RNA virus and was awarded his DSc by the University of Sydney in 1959 . From 1962 he focused on immune reactions, demonstrating that antigens are not present in antibody-producing cells, in support of Burnet's clonal selection theory.
17.
In the late 1950s however, the works of three scientists Burnet ( who largely modified the theory ) gave rise to the clonal selection theory, which proved all the elements of Ehrlich's hypothesis except that the specific receptors that could neutralize the agent were soluble and not membrane-bound.
18.
The clonal selection theory became one of the central concepts of immunology, and Burnet regarded his contributions to the theoretical understanding of the immune system as his greatest contribution to science, Jerne was recognised for his contributions to the conceptualisation of the immune system when he was a co-recipient of the Nobel Prize in 1984.
