Prolongation of the ACT may indicate a deficiency in coagulation factors, thrombocytopenia or platelet dysfunction.
12.
Deficiencies of coagulation factors are associated with clinical bleeding.
13.
Patients in the late stage have significant thrombocytopenia; however, deficiency of coagulation factors is less severe.
14.
This coagulation factor imbalance leads to paradoxical activation of coagulation, resulting in a hypercoagulable state and thrombosis.
15.
Multiple in vitro substrates for thioredoxin have been identified, including ribonuclease, choriogonadotropins, coagulation factors, glucocorticoid receptor, and insulin.
16.
Hepatocytes express blood coagulation factor XII.
17.
Systemic coagulation activation may lead to depletion of circulating coagulation factors and platelets, which subsequently lead to bleeding.
18.
"' Prothrombin activator "'is a complex of a dozen blood coagulation factors that functions in catalyzing prothrombin into thrombin.
19.
Mutations in this gene are associated with vitamin K-dependent coagulation defect and PXE-like disorder with multiple coagulation factor deficiency.
20.
The family appeared to have a hereditary deficiency in an unknown coagulation factor, dubbed Fletcher factor after the family.
