Agglutinin might also be associated with diseases of which the most common is an autoimmune disease known as cold agglutinin disease.
12.
A common complaint among patients with cold agglutinin disease is painful fingers and toes with purplish discoloration associated with cold exposure.
13.
In cold agglutinin disease, the body produces agglutinins or antibodies that coagulate erythrocytes and lyse them at room temperature or lower.
14.
Pathologic cold agglutinins occur at titers over 1 : 1000 and react at 28-31 �C and sometimes at 37 �C.
15.
Cold agglutinins commonly have variable heavy-chain regions encoded by VH, with a distinct idiotype identified by the 9G4 rat murine monoclonal antibody.
16.
House notices that the patient's blood thickens dangerously when his body temperature drops ( cold agglutinin disease ), something that cannot be faked.
17.
The rate of erythrocyte production by the bone marrow is lower than the rate of destruction, thus, individuals with cold agglutinin disease develop a form of anemia.
18.
Mononucleosis is sometimes accompanied by secondary cold agglutinin disease, an autoimmune disease in which abnormal circulating antibodies directed against red blood cells can lead to a form of autoimmune hemolytic anemia.
19.
Cold agglutinin disease usually results from the production of a specific IgM antibody directed against the I / i antigens ( precursors of the ABH and Lewis blood group substances ) on red blood cells ( RBCs ).
20.
"' Cryoglobulinemia "'or "'cryoglobulinaemia "'is a medical condition in which the blood contains large amounts of cryoglobulins proteins ( mostly cold agglutinins, which cause agglutination of red blood cells.
