If the complement response is sufficient, red blood cells are damaged by the membrane attack complex, an effector of the complement cascade.
12.
Elements of the complement cascade can be found in many non-mammalian species including plants, birds, fish, and some species of invertebrates.
13.
The activation of the complement cascade can cause damage to cells, therefore the inhibition of the complement cascade can work as a medicine in certain conditions.
14.
The activation of the complement cascade can cause damage to cells, therefore the inhibition of the complement cascade can work as a medicine in certain conditions.
15.
Shiga-toxin directly activates the alternative complement pathway and also interferes with complement regulation by binding to complement factor H, an inhibitor of the complement cascade.
16.
Lending credibility to this has been the discovery of disease-associated genetic polymorphisms in other elements of the complement cascade including complement component 3 ( C3 ).
17.
In CDC, mAbs bind to specific antigen, leading to activation of the complement cascade, which in turn leads to formation of pores in tumor cells.
18.
It has been shown that CR1 can act as a negative regulator of the complement cascade, mediate immune adherence and phagocytosis and inhibit both the classic and alternative pathways.
19.
These points are of interest because C5a is generated by the interaction of bacteria with blood plasma components to activate the complement cascade which then cleave C5a from Complement component 5.
20.
All of the men were reported to have experienced cytokine release syndrome resulting in angioedema, swelling of skin and mucous membranes, akin to the effects of the complement cascade in severe allergic reaction.
