Bis-choline tetrathiomolybdate is a de-coppering therapy in clinical development against Wilson's disease under the code name WTX101 by Wilson Therapeutics AB . Wilson Therapeutics was founded by HealthCap in 2012.
12.
The results were far more favourable this time, but the onset and intensification of the war with America prevented the re-bolting of the Royal Navy's ships necessary to allow a full-scale coppering programme.
13.
This process lasted several years, after which no significant changes to the coppering system were required and metal plating remained a standard method of protecting a ship's underwater hull until the advent of modern anti-fouling paint.
14.
When the maul was cleaned on Thursday 19 December it appeared that some initials were carved into the handle, perhaps with a seaman's coppering punch : " I . P . " or " J . P . ".
15.
This method is known as coppering, and by its means many delicate little forms, such as stars, rosettes and fine spots can be printed, which would otherwise be quite impossible to produce by hand or machine block printing.
16.
As the coppering was expensive, only the better owners tended to invest in the method, and as a result the use of copper sheathing tended to indicate a well-found and maintained ship, which led to Lloyd's of London charging lower insurance premiums, as the vessels were better risks.
