He joined the recently created Pasteur Institute in 1889 as Roux's collaborator, and discovered with him the diphtheric toxin ( produced by the " Corynebacterium diphtheriae " bacillus ).
12.
The domain is named after " Corynebacterium diphtheriae " dtxR, an iron-specific diphtheria toxin repressor, and " Bacillus subtilis " mntR, a manganese transport regulator.
13.
Examples are the conversion of harmless strains of " Corynebacterium diphtheriae " or " Vibrio cholerae " by bacteriophages to highly virulent ones, which cause diphtheria or cholera, respectively.
14.
The only toxins more lethal to mice are botulinum toxin, produced by close relative " Clostridium botulinum " and the exotoxin produced by " Corynebacterium diphtheriae ", the causative agent of diphtheria.
15.
Well-known exotoxins include : botulinum toxin produced by " Clostridium botulinum "; " Corynebacterium diphtheriae " toxin, produced during life-threatening symptoms of diphtheria; tetanospasmin produced by Clostridium tetani.
16.
Cases of bacterial conjunctivitis that involve the production of membranes or pseudomembranes are associated with Neisseria gonorrhoeae, ?-hemolytic streptococci, and C . diphtheriae . " Corynebacterium diphtheriae " causes membrane formation in conjunctiva of non-immunized children.
17.
One of its best known relatives is " Corynebacterium diphtheriae ", the causative agent of diphtheria . " C . amycolatum " is a common component of the natural flora found on human skin and mucous membranes, and as such, is often disregarded by physicians as a contaminant when found in blood cultures.
18.
Highlights of Park's career included the establishment of the first municipal bacteriological diagnostics laboratory in the United States, the application of toxin-antitoxin vaccines to prevent diphtheria, the demonstration of the persistence of " Corynebacterium diphtheriae " in the throats of people who recovered from diphtheria and its importance in the spread of the disease to others, and the publication of the widely used textbook Pathogenic Microorganisms, co-authored with Anna Williams.
