Furthermore, possible explanations for the photochemical decarboxylation and oxygen radical formation may be the accumulation of repeated dosage, the induction of cytochrome P450I and the emergence of reactive intermediates with covalent binding.
12.
The loss of cytochrome P-450 and monooxygenase activity seen on incubation of liver microsomes with ANTU is likely the result of the covalent binding of atomic sulfur to cytochrome P-450.
13.
Covalent binding of a qABP to the active site of the targeted enzyme will provide direct evidence concerning if the enzyme is responsible for the signal upon release of the quencher and regain of fluorescence.
14.
The available evidence suggests that the pulmonary toxicity of ANTU results, at least in part, from the covalent binding of a cytochrome P-450 monooxygenase catalyzed metabolite of ANTU to pulmonary macromolecules.
15.
"Non-covalent binding of inhibitor " : in this method a peptide, antibody or aptamer are non-covalently bound to the enzyme at low temperature and inhibit its activity.
16.
Such noncovalent ConA-glycoenzyme couplings may be relatively easily reversed by competition with sugars or at acidic pH . If necessary for certain applications, these couplings can be converted to covalent bindings by chemical manipulation.
17.
It is not clear exactly why only these residues are glycated in serum albumin, but it is suggested that non-covalent binding of glucose to serum albumin prior to the covalent bond formation might be the reason.
18.
These proteins may be anchored to the bilayer as a result of hydrophobic interactions between the bilayer and exposed nonpolar residues at the surface of a protein, by specific non-covalent binding interactions with regulatory lipids, or through their attachment to covalently bound lipid anchors.
19.
I thought it meant " covalent bond ", but as a colleague of mine pointed out, it means the partially covalent binding that hydrogen can built to any electronegative atom ( like the bond between the O in one water molecule to the H of another ).
20.
Due to the structure of CYN, which includes sulfate, guanidine and uracil groups, it has been suggested that CYN acts on DNA or RNA . Shaw " et al . " . reported covalent binding of CYN or its metabolites to DNA in mice, Humpage " et al . " also supported this, and in addition postulated that CYN ( or a metabolite ) acts on either the spindle or centromeres during cell division, inducing loss of whole chromosomes.
