| 11. | This reaction is catalyzed by a cyclization domain on the Ser9 NRPS module.
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| 12. | This allows for easier cyclization via a protease or a protease-like enzyme.
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| 13. | As originally described, the Nazarov cyclization involves the activation of a mechanistic pathway.
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| 14. | Deprotection of compound 7 followed by cyclization and iodination results in vinyl iodide 8.
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| 15. | The cyclization of FPP proceeds via a synchronous reaction of trans-antiparallel additions.
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| 16. | The second step is an oxidative cyclization, and step 3 is an isomerization.
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| 17. | However, upon heating cyclization was observed and the reaction yielded NCAs and alkylchlorides.
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| 18. | The NCA method allows rapid cyclization to produce the target peptide with high yield.
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| 19. | Hundreds of steroids are found in plants, animals and cyclization of the triterpene squalene.
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| 20. | Their approach employed an aryne cyclization to close the final ring of the natural product.
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