Other membrane activation events can either prime mast cells for subsequent degranulation or act in synergy with Fc?RI signal transduction.
12.
It is a lysosomal protein stored in azurophilic granules of the neutrophil and released into the extracellular space during degranulation.
13.
Neurotensin is involved in many processes including mast cell degranulation and regulation of central nervous system dopaminergic and cholinergic circuits.
14.
Antibodies will also trigger vasoactive amine degranulation to contribute to immunity against certain types of antigens ( helminths, allergens ).
15.
They block a calcium channel essential for mast cell degranulation, stabilizing the cell, thus preventing the release of histamine.
16.
If the degranulation is widespread, it can cause a shock-like syndrome similar to that of an allergic reaction.
17.
The degranulation of mast cells is very easily triggered, as was evidenced by the controversial Nature paper by Jacques Benveniste.
18.
Interleukin-8 is a key mediator associated with inflammation where it plays a key role in neutrophil recruitment and neutrophil degranulation.
19.
Crosslinking of the Fc?RI via IgE-antigen complexes leads to degranulation of mast cells or basophils and release of inflammatory mediators.
20.
Under laboratory conditions, degranulation of isolated basophils can also be induced with antibodies to the Fc?RI?, which crosslink the receptor.
