In a pioneering study by Bernstein and Bamburg, it was observed that the actin-binding protein " actin depolymerisation factor ( ADF ) / cofilin ", a factor that promotes actin filament depolymerisation, competed with tropomyosin for binding to the actin filament.
12.
Depolymerisation is an indirect method of analysis allowing to gain informations such as average degree of polymerisation, percentage of galloylation, etc . The depolymerised sample can be injected on a mass spectrometer with an electrospray ionization source, only able to form ions with smaller molecules.
