Proteolysis of corneodesmosomes is required for desquamation, the shedding of corneocytes from the outer layer of the epidermis.
12.
This process is a normal protective mechanism of the skin to prevent pathogens from colonizing the skin, and is referred to as desquamation.
13.
Outside of medical therapy, when moist desquamation is seen in the setting of nuclear warfare, the condition is generally thought to be fatal.
14.
KLK5 is able to undergo autoactivation, as well as activating KLK7 and KLK14, suggesting a KLK skin cascade is responsible for coordinating desquamation.
15.
In healthy skin, desquamation is an invisible process and the stratum corneum is turned over completely within 2 4 weeks, while maintaining the tissue thickness.
16.
Within each area, the severity is estimated by three clinical signs : erythema ( redness ), induration ( thickness ) and desquamation ( scaling ).
17.
Desquamation of the skin is likely controlled by KLK5, KLK7 and KLK14, which are expressed in the outermost layer of the epidermis and cleave cellular adhesion proteins.
18.
This decrease could contribute to the altered desquamation process seen in the disease, since the clinical improvement associated with retinoid treatment is accompanied by increased expression of involucrin.
19.
The change in the structure affects the epithelium, some cells of which may become entrapped in the rugged membrane and fail to migrate to the surface where they should undergo desquamation.
20.
Daniel Sennert of Wittenberg described the classical'scarlatinal desquamation'in 1572 and was also the first to describe the early arthritis, scarlatinal dropsy, and ascites associated with the disease.
