Several clinical trials are now ongoing that investigate the therapeutic value of targeting CTGF in fibrosis, diabetic nephropathy, and pancreatic cancer.
12.
GWAS show that genetic variations of the CPVL gene are associated with susceptibility to diabetic nephropathy in European Americans, Japanese and Chinese.
13.
PTECs also participate in the progression of tubulointerstitial injury due to glomerulonephritis, ischemia, interstitial nephritis, vascular injury, and diabetic nephropathy.
14.
Increased glomerular and mesangial deposition of collagen IV occurs in diabetic nephropathy and increased urinary levels are associated with the extent of renal injury.
15.
Lower plasma glutathione peroxide levels were also observed in patients with type 2 diabetes with macroalbuminuria and this was correlated to the stage of diabetic nephropathy.
16.
"' Plozalizumab "'( INN ) is a humanized monoclonal antibody designed for the treatment of diabetic nephropathy and arteriovenous graft patency.
17.
In addition to fibrosis, aberrant CTGF expression is also associated with many types of malignancies, diabetic nephropathy and retinopathy, arthritis, and cardiovascular diseases.
18.
:Oops, never mind, stupid me, it's an indication of Diabetic nephropathy . talk ) 20 : 05, 5 April 2009 ( UTC)
19.
The glomeruli of the kidneys are especially sensitive-see diabetic nephropathy-where protein leakage caused by late-stage angiopathy results in diagnostic proteinuria and eventually renal failure.
20.
The extract ( 379 mg / kg ) was found to reduce blood glucose levels and slow the development of diabetic nephropathy in mice treated with streptozocin to induce diabetes.
