ALOX5 metabolizes the omega-6 fatty acid, Arachidonic acid ( AA, i . e . 5 " Z ", 8 " Z ", 11 " Z ", 15 " Z "-eicosatrienoic acid ), to 5-hydroperoxyeicosatetraenoic acid ( MRP1 transporter ( ABCC1 ) and is rapidly converted to LTD4 and then to LTE4 ) by cell surface-attached gamma-glutamyltransferase and dipeptidase peptidase enzymes.
