| 11. | Dimenhydrinate is a combination of two drugs : diphenhydramine and 8-chlorotheophylline.
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| 12. | Topical formulations containing diphenhydramine are also available but may further irritate the skin.
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| 13. | Diphenhydramine was originally marketed under the brand name Benadryl in the early 1950s.
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| 14. | Histamine blockers such as diphenhydramine or meclozine may be used in rescue treatment.
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| 15. | Diphenhydramine hydrochloride is known to have hypnotic effects and is non-habit forming.
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| 16. | In the 1960s, diphenhydramine was found to inhibit reuptake of the neurotransmitter serotonin.
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| 17. | By weight, dimenhydrinate is between 53 % to 55.5 % diphenhydramine.
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| 18. | Diphenhydramine hydrochloride is also marketed as a sleep aid in Canada under the same name.
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| 19. | Topical formulations of diphenhydramine are available, including creams, lotions, gels, and sprays.
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| 20. | Synthetic compounds such as diphenhydramine ( Benadryl ) and dimenhydrinate ( Dramamine ) are also deliriants.
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