The morphologic changes have also been described in myxedema associated with panhypopituitarism, vitamin B12 and folate deficiency, multiple myeloma, enteroviral infections, malaria, muscular dystrophy, leukemoid reaction secondary to metastases to the bone marrow, and drug sensitivity, sulfa and valproate toxicities are examples.
12.
The lupus erythematosus ( LE ) cell test was commonly used for diagnosis, but it is no longer used because the LE cells are only found in 50 75 % of SLE cases, and they are also found in some people with rheumatoid arthritis, scleroderma, and drug sensitivities.
13.
This thinking may also help explain how a given cell can reversibly switch phenotypes as seen in EMT and MET or for that matter, a drug-sensitive cell from developing resistance and switching back to drug sensitivity, or the transformation of a normal cell to a malignant one and its reversal to normalcy.
14.
MethoCult " ! can be used to : quantitate and characterize hematopoietic progenitors from various samples using CFU assays; quantitate primitive hematopoietic progenitors from LTC-IC assays; evaluate hematopoietic cell growth and differentiation, and screen for new growth factors and / or inhibitors of hematopoiesis; quantitate hematopoietic progenitors following ex vivo expansion or T cell depletion; and test in vitro drug sensitivity of hematopoietic progenitors.
