Adult articular calcified cartilage is penetrated by vascular buds, and new bone produced in the vascular space in a process similar to endochondral ossification at the physis.
12.
Endochondral ossification begins with points in the cartilage called " primary ossification centers . " They mostly appear during fetal development, though a few short bones begin their primary ossification after birth.
13.
.. . that "'endochondral ossification "'is one of two types of bone formation and is the process responsible for much of the bone growth in vertebrate skeletons?
14.
Endochondral ossification, begins by the end of the embryonic period and primary ossification centers are present in all long bones of the limbs, including the femur, by the 12th week of development.
15.
In development the formation of bone can either occur via a Cartilage template initially formed by the MSCs that then gets ossified through a process called endochondral ossification or directly from MSC hypoxia, which then results in the differentiation of the periosteal MSCs into articular chondrocytes, i . e . cells similar to those found in the joint cartilage.
