| 11. | After the fusion of the late endosome with the lysosome, lysosomal sialidases remove sialic acid residues.
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| 12. | The cargo proteins are then trafficked to the lysosome via the late endosome independently of the IGF2Rs.
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| 13. | Once formed, the endosome combines with a structure known as a multivesicular body ( MVB ).
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| 14. | Instead, it transforms into a reticulate body ( RB ) and begins to replicate within the endosome.
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| 15. | Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis.
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| 16. | Secondly, acidification of the endosome triggers the formation of a pore through which the GTD is translocated.
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| 17. | Receptor binding is the first step required for entry into the cell via endocytosis in an acidic endosome.
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| 18. | It is localized to the endosomal compartment of the cell with the LRR region facing into the endosome.
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| 19. | VP1 has a conserved phospholipase A2 domain which is used by the viron to escape from the endosome.
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| 20. | The virus attach to the cell surface via specific receptors and are taken up by an endosome being formed.
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