Now I have been drinking milk and milk products for some time and I may be getting more tolerant perhaps due to enzyme induction, or perhaps as the article suggest due to gut bacteria adjusting to it . user : 80.0 . 125.54
12.
Although all known members of the class possess relevant enzyme induction capabilities the degree of inhibition overall as well as the impact on each specific enzyme span a broad range with phenobarbital and secobarbital being the most potent enzyme inducers and butalbital and talbutal being among the weakest enzyme inducers in the class.
13.
As with most barbiturates, butalbital is a general inducer of P450 enzymes in both rodents and humans, particularly CYP3A4 ( hence inducing its own metabolism ), CYP2D6, and CYP2C9, although its P450 enzyme induction capability is far less than that of equivalent doses of phenobarbital or secobarbital ( the most potent known enzyme inducers in the barbiturate molecular family ).
