The secretion of hepcidin is inhibited by another hormone, erythroferrone, produced by erythroblasts in response to erythropoietin, and identified in 2014.
12.
The nucleus is expelled during the process of differentiation from an erythroblast to a reticulocyte, which is the immediate precursor of the mature erythrocyte.
13.
Most of the expression is in the proerythroblast ( P ) stage, and a minor amount in the basophilic erythroblast ( B ) stage.
14.
The protein encoded by this gene may be involved in the transitioning of erythroblasts from a highly proliferative state to a terminal phase of differentiation.
15.
Erythroferrone, produced in erythroblasts, has been identified as inhibiting hepcidin and so providing more iron for hemoglobin synthesis in situations such as stress erythropoiesis.
16.
The erythroblast is then able to remove its nucleus, which is in turn ingested and broken down by the macrophages, to become a mature erythrocyte.
17.
During red blood cell maturation, GATA1 activates nearly all erythroid-specific genes while silencing genes associated with the immature proliferative red blood cell precursor cells ( erythroblasts ).
18.
Fli-1 is a member of the ETS transcription factor family that was first identified in Ras pathway, and resulting in massive Epo-independent proliferation of erythroblasts.
19.
It has been documented that fetal cells such as fetal erythroblasts as well as cell-free fetal DNA are increased in the maternal circulation in women who develop pre-eclampsia.
20.
During this process ICAM-4 binds to VLA-4, an erythroblast binding site, on adjacent erythroblasts and to ?v integrins on macrophages to help stabilise the erythroblastic islands.
