A rough calculation shows that his intake was equivalent to about 6 or 7 marijuana cigarettes per dose, i . e . at the hallucinatory rather than at the euphoriant level prevalent in contemporary North American use.
12.
At the top our efforts were rewarded with a euphoriant view : wave after wave of craggy, glacially scrubbed mountains _ the core of the Brooks Range _ wind-hammered and barren, looking like huge mounds of volcanic ash.
13.
In light of this observation, the original paper and both reviews suggest that phenethylamine plays a prominent role in mediating the mood-enhancing euphoric effects of a runner's high, as both phenethylamine and amphetamine are potent euphoriants.
14.
These neurons are activated directly or indirectly by euphoriant drugs ( e . g ., amphetamine, opiates, etc . ) and by participating in rewarding experiences ( e . g ., sex, music, exercise, etc . ).
15.
Some NMDA receptor antagonists, such as ketamine, dextromethorphan ( DXM ), phencyclidine ( PCP ), methoxetamine ( MXE ), and nitrous oxide ( N 2 O ), are popular recreational drugs used for their dissociative, hallucinogenic, and euphoriant properties.
16.
However, systematic study of these chemicals is lacking, due to the off-patent nature of 5-HTP, and the legal control of MDMA . In addition, other serotonergic euphoriant drugs, like the psychedelic LSD, have been reportedly used to drastically increase sexual pleasure.
17.
Thus, because anandamide is a euphoriant and aerobic exercise is associated with euphoric effects, it has been proposed that anandamide partly mediates the short-term mood-lifting effects of exercise ( e . g ., the euphoria of a runner's high ) via exercise-induced increases in its synthesis.
18.
The UN reported shortly after the beginning of marketing of ketobemidone that it was " nine times more active " than methadone, presumably as a euphoriant, and was thus labelled as extra-dangerous along with dextromoramide ( " three times more active than heroin " ) and several other synthetics about the same time, as expanded upon below.
19.
Continuous aerobic exercise can induce a transient state of euphoria, colloquially known as a " runner's high " in distance running or a " rower's high " in crew, through the increased biosynthesis of at least three euphoriant neurochemicals : anandamide ( an endocannabinoid ), ?-endorphin ( an endogenous opioid ), and phenethylamine ( a trace amine and amphetamine analog ).
20.
Two reviews noted a study where the mean 24 hour urinary phenylacetic acid concentration following just 30 minutes of intense exercise rose 77 % above its base level; Because of the pharmacological relationship between phenethylamine and amphetamine, the original paper and both reviews suggest that phenethylamine plays a prominent role in mediating the mood-enhancing euphoric effects of a runner's high, as both phenethylamine and amphetamine are potent euphoriants.
