In the same study, glutathione reductase deficiency was associated with cataracts and favism in one patient and their family, and with severe unconjugated hyperbilirubinemia in another patient.
12.
It has been suggested that the prohibition of beans was to avoid favism; susceptible people may develop hemolytic anemia as a result of eating beans, or even of walking through a field where bean plants are in flower.
13.
Favism fit with Bowman s lifelong focus on inherited blood diseases and led to a series of important discoveries about the genetics of these diseases and the populations they affect, especially in the Middle East, Africa and America.
14.
In Favism, patients lack glucose-6-phosphate dehydrogenase, an enzyme in their pentose phosphate pathway that reduces NADP + to NADPH while catalyzing the conversion of glucose-6-phosphate to 6-phosphoglucono-?-lactone.
15.
Some epidemiological and " in vitro " studies suggest the hemolysis resulting from favism acts as protection from malaria, because certain species of malarial protozoa, such as " Plasmodium falciparum ", are very sensitive to oxidative damage due to deficiency of the glucose-6-phosphate dehydrogenase enzyme, which would otherwise protect from oxidative damage via production of glutathione reductase.
