| 11. | Also, insulin resistance often is associated with a hypercoagulable state ( impaired fibrinolysis ) and increased inflammatory cytokine levels.
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| 12. | The circulating enzyme plasmin, the main enzyme of fibrinolysis, cleaves the fibrin gel in a number of places.
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| 13. | Plasminogen activator inhibitor-1, an inhibitor of fibrinolysis, is present in higher levels in people with obesity.
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| 14. | Thrombomodulin functions as a thrombin-activatable fibrinolysis inhibitor ( TAFI, aka carboxypeptidase B2 ) into its active form.
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| 15. | Tranexamic acid and aminocaproic acid inhibit fibrinolysis, and lead to a " de facto " reduced bleeding rate.
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| 16. | In DIC, the processes of coagulation and fibrinolysis are dysregulated, and the result is widespread clotting with resultant bleeding.
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| 17. | Antifibrinolytics, such as aminocaproic acid ( ?-aminocaproic acid ) and tranexamic acid are used as inhibitors of fibrinolysis.
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| 18. | Presumably, lower PAI levels would lead to less suppression of fibrinolysis and conversely a more rapid degradation of the fibrin.
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| 19. | In vitro studies confirmed the fibrinolysis inhibition capacity of CU-2010 when present at concentrations between 100 to 1000 nM.
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| 20. | Any blood clot forms due to an imbalance between coagulation ( the formation of the insoluble blood protein fibrin ) and fibrinolysis.
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